Dec 22, 2014
Osmotic gradient is just the tonic for wounded epithelia
Rapid wound repair is generally thought to be initiated by intrinsic cues, such as changes in the structure or mechanics of damaged tissues. Gault et al. reveal that an extrinsic signal — the osmolarity of the external environment — can stimulate wound closure in zebrafish by inducing epithelial cell migration. This biosights episode presents the paper by Gault et al. from the December 22, 2014, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Philipp Niethammer (Memorial Sloan Kettering Cancer Center, New York). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
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The Rockefeller University Press