Dec 23, 2013
Tumor cells WASH away the extracellular matrix
Tumor cells invade through extracellular matrices by forming actin-rich structures called invadopodia, which contain the transmembrane matrix metalloproteinase MT1-MMP. Monteiro et al. reveal that the Arp2/3 activating protein WASH works with the exocyst complex to deliver MT1-MMP from late endosomes to the invadopodial plasma membrane. This biosights episode presents the paper by Monteiro et al. from the December 23, 2013, issue of The Journal of Cell Biology and includes an interview with senior author Philippe Chavrier (Institut Curie, Paris, France). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
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