Jul 8, 2013
Vinculin delivers a clutch performance
At the leading edge of migrating cells, actin assembly and membrane protrusion are closely coupled with the formation of integrin-based focal adhesions that attach to the extracellular matrix. Thievessen et al. reveal that the focal adhesion protein vinculin acts as part of a molecular clutch that engages actin flow to coordinate actin and focal adhesion dynamics. This biosights episode presents the paper by Thievessen et al. from the July 8, 2013, issue of The Journal of Cell Biology and includes an interview with senior author Clare Waterman (NHLBI, Bethesda, MD). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
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