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Jun 9, 2014

Rab18 tilts the balance of ER structure

The endoplasmic reticulum consists of peripheral tubular networks connected to sheet-like domains surrounding the nucleus. Gerondopoulos et al. reveal that the Rab3GAP complex, which is mutated in the neurodevelopmental disorder Warburg Micro Syndrome, is a guanine nucleotide exchange factor that activates the small GTPase Rab18 (also mutated in Warburg Micro Syndrome) to control the balance between ER tubules and sheets. This biosights episode presents the paper by Gerondopoulos et al. from the June 9, 2014, issue of The Journal of Cell Biology and includes an interview with senior author Francis Barr (University of Oxford, UK). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.


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