Mar 17, 2014
Blebs lead the way in Dictyostelium chemotaxis
Membrane blebs can help the leading edge of migrating cells protrude forwards, but the contribution of blebs to the motility of Dictyostelium cells is unclear. Zatulovskiy et al. reveal that blebs form at the front of chemotaxing Dictyostelium cells, particularly when the cells are faced with a mechanically resistant environment, and that this process is guided by a PI3-kinase-dependent signaling pathway. This biosights episode presents the paper by Zatulovskiy et al. from the March 17, 2014, issue of The Journal of Cell Biology and includes an interview with senior author Robert Kay (MRC Laboratory of Molecular Biology, Cambridge, UK). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
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