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Mar 6, 2017

Actin isoforms divide their responsibilities in motoneurons

Actin dynamics are crucial for axon growth and branching, but most studies have only focused on the role of β-actin. Moradi et al. reveal that α-, β-, and γ-actin have different functions in motoneuron axons; locally translated α-actin forms stable actin filaments that promote the formation of axonal branches, whereas β-actin regulates growth cone dynamics. This biosights episode presents the paper by Moradi et al. from the March 6th, 2017, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Michael Sendtner (University Hospital Würzburg, Würzburg, Germany). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.


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