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May 7, 2018

BBSome trains provide receptors a passage out of cilia

Many G protein–coupled receptors accumulate in the membrane of primary cilia and then exit this sensory organelle when their signaling pathway is activated. Ye et al. reveal that the BBSome complex facilitates the signal-dependent exit of GPCRs by moving them across a diffusion barrier located at the ciliary transition zone, although the receptors must then cross a second, periciliary diffusion barrier to completely exit the cilium. This biosights episode presents the paper by Ye et al. from the May 7th, 2018, issue of the Journal of Cell Biology and includes an interview with the paper's senior author, Maxence Nachury (University of California, San Francisco). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.


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