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Nov 21, 2016

Formin’ arcs at the immunological synapse

When a T cell encounters an antigen-presenting cell, it dramatically reorganizes its cytoskeleton to form a specialized contact site called the immunological synapse. Murugesan et al. use superresolution microscopy to reveal that the medial region of the synapse contains a contractile network of formin-generated actomyosin arcs that sweep T cell receptor microclusters toward the center of the synapse. This biosights episode presents the paper by Murugesan et al. from the November 7th, 2016, issue of The Journal of Cell Biology and includes an interview with the paper’s senior author, John Hammer (NHLBI, Bethesda, MD). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.