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Apr 3, 2017

How Chlamydia help mitochondria keep it together

The obligate intracellular bacterium Chlamydia trachomatis must keep its host cell alive, even though it produces reactive oxygen species that expose the host cell to oxidative stress. Chowdhury et al. reveal that Chlamydia mitigates this oxidative stress by down-regulating the mitochondrial fission protein DRP1 via a microRNA- and p53-dependent pathway, thereby maintaining the mitochondrial network and ATP production to promote host cell survival and bacterial growth. This biosights episode presents the paper by Chowdhury et al. from the April 3rd, 2017, issue of The Journal of Cell Biology and includes an interview with two of the paper's authors, Suvagata Roy Chowdhury and Thomas Rudel (University of Würzburg, Würzburg, Germany). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.


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