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Sep 26, 2016

An iron hand controls endosome-mitochondria contacts

In erythroid cells, endocytosed iron is directly transferred into mitochondria at dynamic endosome-mitochondria contacts. Das et al. reveal that this process also occurs in epithelial cells, and that the motility of endosomes, and the duration of their interactions with mitochondria, is modulated by intra-endosomal iron release from transferrin. This biosights episode presents the paper by Das et al. from the September 26th, 2016, issue of The Journal of Cell Biology and includes an interview with the paper’s senior author, Margarida Barroso (Albany Medical College, Albany, NY). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.


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