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Jan 2, 2018

Ring out your dead: MRCK╬▒ cleavage triggers epithelial extrusion

Dying epithelial cells are extruded from the tissue by a basal actomyosin ring formed in neighboring, healthy cells. Gagliardi et al. reveal that epithelial extrusion is also driven by actin rearrangements in the apoptotic cell, where cleavage of the...

Nov 6, 2017

Cancer-associated fibroblasts lay the tracks for directional migration

Cancer-associated fibroblasts, or CAFs, regulate tumor progression by secreting chemokines and remodeling the extracellular matrix. Erdogan et al. reveal that the CAF-dependent alignment of fibronectin promotes directional cancer cell migration. This...

Oct 2, 2017

Drp1 cuts off mitophagy

Misfolded mitochondrial proteins can be eliminated by Parkin-dependent mitophagy but how this process selectively removes damaged mitochondrial regions is unclear. Burman et al. reveal that protein aggregates in the mitochondrial matrix trigger a local accumulation of Parkin on the mitochondrial...

Sep 4, 2017

Synaptic activity shifts dendritic lysosomes

Invading pathogens or other toxic agents can trigger the assembly of the inflammasome adaptor ASC into large, intracellular specks that activate caspase-1 to initiate a proinflammatory cell death called pyroptosis. Kuri et al. follow the dynamics of ASC speck formation in...

Aug 7, 2017

Synaptic activity shifts dendritic lysosomes

Lysosomes are known to exist in both the cell body and axon of neurons, but whether they also localize to dendrites is unclear. Goo et al. reveal that lysosomes do exist in dendrites and dendritic spines, and that their trafficking in this region of neurons is regulated by...