Dec 27, 2010
Dynamic microtubules assemble into a steady state bipolar spindle structure but precisely how this is achieved is unclear. Loughlin et al. develop a computational model that predicts how a few key activities organize microtubules in Xenopus meiotic spindles. This biosights episode presents the paper by Loughlin et al....
Nov 29, 2010
Centrosome positioning is thought to be important for both neuronal migration and axonogenesis. To investigate centrosome dynamics in vivo, Distel et al. develop a new method to simultaneously visualize multiple subcellular compartments in live zebrafish embryos. This biosights episode presents the paper by Distel et...
Nov 1, 2010
Most migrating cells place their centrosome in front of the nucleus, facing the direction in which the cell is moving. Manneville et al. identify a signaling pathway that moves the centrosome into position by recruiting the motor protein dynein to leading edge microtubules. This biosights episode presents the paper by...
Oct 4, 2010
Many cellular processes, including polarization and differentiation, require the nucleus to move to a specific location within the cytoplasm. Fridolfsson and Starr reveal how the microtubule motors dynein and kinesin-1 control the bi-directional movements of nuclei in the embryonic hypoderm of C. elegans. This...
Sep 6, 2010
During an immune response, T cells move into tissues from the vasculature by crossing the endothelial cell layer lining blood vessel walls. Heasman et al. reveal that this transendothelial migration requires signaling at both the front and back of leukocytes by the small GTPase RhoA. This biosights episode presents the...