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Aug 7, 2017

Synaptic activity shifts dendritic lysosomes

Lysosomes are known to exist in both the cell body and axon of neurons, but whether they also localize to dendrites is unclear. Goo et al. reveal that lysosomes do exist in dendrites and dendritic spines, and that their trafficking in this region of neurons is regulated by synaptic activity. This biosights episode presents the paper by Goo et al. from the August 7th, 2017, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Gentry Patrick (University of California, San Diego). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.


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