Preview Mode Links will not work in preview mode

biosights

Jan 24, 2011

The transcription factor HIF-1α is essential for a cell's response to low oxygen conditions. Carbonaro et al. demonstrate that production of HIF-1α protein is regulated by dynamic microtubules and that microtubule-targeting drugs shift HIF-1α mRNA into cytoplasmic P-bodies, where its translation is repressed by...