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biosights

Dec 23, 2013

Tumor cells WASH away the extracellular matrix

Tumor cells invade through extracellular matrices by forming actin-rich structures called invadopodia, which contain the transmembrane matrix metalloproteinase MT1-MMP. Monteiro et al. reveal that the Arp2/3 activating protein WASH works with the exocyst complex to deliver...


Nov 25, 2013

When a growing axon nears its target, it arborizes, or branches, to form numerous synaptic connections. Campbell and Okamoto reveal that localized caspase activation... (more)


Oct 28, 2013

A framework for understanding muscle microtubules

The microtubules of skeletal muscle fibers are arranged into an orthogonal grid, but how this network is formed is unknown. Oddoux et al. reveal that the network is built by dynamic microtubules nucleated from Golgi elements. This biosights episode presents the paper by...


Sep 30, 2013

WIn addition to specialized actin structures such as lamellipodia and stress fibers, cells are thought to contain a contractile actomyosin matrix that maintains cell shape.... (more)


Sep 2, 2013

When a T cell encounters a target antigen-presenting cell, it moves its centrosome to the immunological synapse that connects the two cells. Yi et al. reveal that centrosome repositioning is a biphasic process driven by the dynein-dependent capture and depolymerization of microtubules...