Sep 2, 2013
Shrinking microtubules pull the centrosome into place
When a T cell encounters a target antigen-presenting cell, it moves its centrosome to the immunological synapse that connects the two cells. Yi et al. reveal that centrosome repositioning is a biphasic process driven by the dynein-dependent capture and depolymerization of microtubules. This biosights episode presents the paper by Yi et al. from the September 2, 2013, issue of The Journal of Cell Biology and includes an interview with senior author John Hammer (NHLBI, Bethesda, MD). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
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The Rockefeller University Press