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biosights

Oct 29, 2012

A stiff test for collectively migrating cells

The mechanical properties of the extracellular matrix are known to regulate the migration of single cells, but whether substrate stiffness also affects collective cell migration is unclear. Ng et al. reveal that epithelial sheets move faster on stiffer matrices due to...


Oct 1, 2012

The position of the mitotic spindle is controlled by the microtubule-based motor dynein and a ternary complex of the proteins NuMA, LGN, and Ga. Kotak et al. demonstrate that the ternary complex's primary function is to localize dynein to the cell cortex...