Jun 13, 2011
The mammalian Golgi apparatus exists as a continuous ribbon that clusters around the centrosome, but the significance of this organization is unclear. Hurtado et al. identify truncation mutants of the protein AKAP450 that differentially affect Golgi integrity and positioning, and use these mutants to investigate how the Golgi's organization contributes to its function in cell polarization, migration, and ciliogenesis. This biosights episode presents the paper by Hurtado et al. from the May 30, 2011, issue of The Journal of Cell Biology, and includes an interview with senior author Rosa Rios (CABIMER, Seville, Spain). Produced by Caitlin Sedwick and Ben Short.
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